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KMID : 0602820100160010033
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Korean Journal of Bronchoesophagology
2010 Volume.16 No. 1 p.33 ~ p.38
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Biodistribution of Inhaled Titania (TiO2) Nanoparticles in Rats
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Choi Se-Hoon
Park Kay-Hyun
Jheon Sang-Hoon
Kim Joo-Hyun
Chung Jin-Haeng
Cho So-Hye
Park Jong-Ku
Kim Tae-Heon
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Abstract
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Purpose:Titania nanomaterials are widely used as cosmetics and dyes, however the impacts on human health are uncertain, We investigated the biodistribution of inhaled titania nanoparticles in rats,
Methods:Eight weeks-old SD rats were intubated and inhaled with 3 mg titania nanoparticles, twice a week, for 2 weeks, After inhalation, the rats were sacrificed and tissues or heart, lung. intestine, brain, and liver were obtained, We investigated the tissues with optical microscope (OM), transmission electron microscope (EM), scanning EM, And to analyze titania concentration of each tissue, we lysed the tissues with radioimmunoprecipitation assay (RlPA) lysis buffer or acid.
Results:Granulation tissues in lung were confirmed on the optical microscope, however the other organs had no abnormalities in OM images, In EM images, the rats which inhaled titania nanoparticles showed calcium deposition at heart, brain, and intestine, Titania concentration in lung was increased on the inhaled rat sacrificed I month after last exposure.
Conclusions: Inhaled titania nanoparticles is thought to be deposited and make inflammatory reaction in lung, and the deposition was not efficiently cleared over a month. However inhaled titania nanoparticles may rarely pass through the alveolus-blood barrier and distribute to other organs of the bod.
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KEYWORD
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Titania (Titanium dioxide, TiO2), Nanoparticles, Inhalation, Lung, Toxicity
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